Bootstrap analysis of multivariate failure time data.

Bootstrap analysis of multivariate failure time data.: " Bootstrap analysis of multivariate failure time data. Stat Med. 2005 Oct 19;24(22):3387-3400 Authors: Monaco J, Cai J, Grizzle J Multivariate failure time data often arise in research. Cox proportional hazards modelling is a widely used method of analysing failure time data for independent observations. However, when failure times are correlated the Cox proportional hazards model does not yield valid estimates of standard errors or significance tests. Many methods for the analysis of multivariate failure time data have been proposed. These methods commonly test hypotheses about the regression parameters, a practice which averages the treatment effect across time. The purpose of this paper is to examine the bootstrap method for obtaining standard errors in the multivariate failure time case, particularly when the focus is the survival probability or the treatment effect at a single time point such as in a surgical trial. Our motivating example comes from the Asymptomatic Carotid and Atherosclerosis Study (ACAS) in which the outcome of stroke or perioperative complications could be observed for either or both carotid arteries within each patient. Extensive simulation studies were conducted to examine the bootstrap procedure for analysing correlated failure time data under a variety of conditions incl"