Normal Limits

"Chance is the very guide of life"

"In practical medicine the facts are far too few for them to enter into the calculus of probabilities... in applied medicine we are always concerned with the individual" -- S. D. Poisson

October 23, 2005

Annals of IM - Prevention of Exacerbations of COPD with Tiotropium, a Once-Daily Inhaled Anticholinergic Bronchodilator

This multi-center, double-blinded RCT of 26 VAs compared the effects of inhaled tiotropium QD versus placebo in patients with COPD, in terms of frequency of exacerbations and hospitalizations.

Patients are:
  • > 40yo
  • Cigarette smoking hx >= 10 pack-years
  • Clinical Dx of COPD
  • FEV1 <>
  • Free of significant co-morbidities or other pulmonary diseases such as asthma.


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