Annals of IM - Prevention of Exacerbations of COPD with Tiotropium, a Once-Daily Inhaled Anticholinergic Bronchodilator

This multi-center, double-blinded RCT of 26 VAs compared the effects of inhaled tiotropium QD versus placebo in patients with COPD, in terms of frequency of exacerbations and hospitalizations.

Patients are:

• > 40yo
• Cigarette smoking hx >= 10 pack-years
• Clinical Dx of COPD
• FEV1 <>
• Free of significant co-morbidities or other pulmonary diseases such as asthma.

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